[DeRosa_ITA]

Caffeine and muscle cramps: a stimulating connection.

"To date, no study of the possible relationship
between caffeine and muscle cramps in healthy humans is
available."
...
...
"We hypothesize that caffeine may act in synergy with
other metabolites, electrolytes, neuronal excitation and inhibition
patterns as well as genetic factors to lower an
overall threshold for inducing muscle cramps, where none
of these factors per se may suffice."