[DeRosa_ITA]

Zitat von pinkpoison

Was mich interessieren würde, worüber ich aber bislang noch nichts gefunden habe, wäre, ob durch operative Maßnahmen wie Fettabsaugen die Zahl der Fettzellen dauerhaft reduziert wird, oder ob da epigenetische Effekte reinspielen, die eine Umprogrammierung der DNA bewirken, so dass so was nichts bringt.

Growth. 1978 Dec;42(4):469-77.
The effects of lipectomy on remaining adipose tissue depots in the Sprague Dawley rat.
Larson KA, Anderson DB.
Abstract
Adult male castrate Sprague Dawley rats were subjected to surgical removal of the right inguinal and both epididymal fat depots. Lipectomized rats were not significantly different from controls in total body fat at approximately 13 weeks after surgery suggesting a compensatory fat gain in response to the lipectomy. Mean wet weight of the major individual fat depots dissected from lipectomized rats exceeded those of the control rats with the exception of surgically excised depots. The generalized trend for the adipose tissue mass to compensate in response to lipectomy was in part due to a partial regeneration of the excised inguinal fat depot. It was observed that the cellular nature of the fat compensation was dependent on the location of the tissue. The major internal depots compensated by a significant increase in average fat cell size, whereas the major subcutaneous depot (inguinal) compensated by a significant increase in the apparent fat cell number with no change in cell size.



Neurosci Biobehav Rev. 2001 Jan;25(1):15-28.
The regulation of total body fat: lessons learned from lipectomy studies.
Mauer MM, Harris RB, Bartness TJ.
Department of Biology and the Neurobiology and Behavior Program, Georgia State University, University Plaza, Atlanta, GA 30303-3083, USA.
Abstract
Surgical removal of body fat (partial lipectomy) is a means of directly reducing fat such that metabolic and behavioral responses can be readily attributed to the lipid deficit. If total body fat is regulated, then lipectomy should trigger compensatory increases in nonexcised white adipose tissue (WAT) mass and/or regrowth at excision sites. Many species, including laboratory rats and mice, show lipectomy-induced compensatory recovery of body fat. Those animals exhibiting naturally occurring annual adiposity cycles, such as ground squirrels and hamsters, do so most impressively reaching seasonally appropriate body fat levels indistinguishable from controls. Reparation of the lipid deficit occurs without an increase in food intake, and generally through enlargement of non-excised WAT mass, rather than regrowth of excised WAT. A body fat regulatory system involving humoral and sensory neural inputs to the brain as well as sympathetic neural outputs from brain to adipose tissue is presented. Collectively, the lipectomy model appears useful for testing mechanisms controlling adiposity, or individual depot growth, and offers insight into how lipid stores fluctuate naturally.